Can we really derive etiology from human-based studies?

نویسنده

  • J R Marshall
چکیده

This paper discusses the need for and limitations of human-based stud ies of diet and cancer. Four problems of such studies remain especially acute: assessment and monitoring of dietary practice; assessment of com pliance in diet change studies; validation of dietary questionnaires; and the use of intermediate biological end points. These limit human-based studies' utilization of recent advances in the cellular and molecular biology of cancer. Those researchers who emphasize human-based studies cannot proceed without acknowledgment of and interface with these advances, which promise more precise definition of both exposure and disease and may facilitate evaluation of associations of dietary practice and carcinogenesis in the context of human-based studies. To take advantage of these advances will require critical attention to the causal mechanisms by which intermediate biological end points link dietary exposures with cancer risk.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Pill Really Can Be Mightier Than the Sword: A Response to Recent Commentaries

We appreciate the four commentaries that add new material and fresh perspectives to our article “The pill is mightier than the sword.” In emphasizing the role of voluntary family planning and girls’ education as achievable strategies with a potential to make the world a more peaceable place, we did not mean to oversimplify or disregard the intrinsic complexity of human conflict. On the whole, t...

متن کامل

Sucrose, High Fructose Corn Syrup 55% and Fructose, Metabolism and Potential Health Effects: What Do We Really Know?

There are a lot of discussions and controversy about sucrose and other sweeteners regarding their metabolism and health effects. These concerns are often arising by speculation based on limited data or few studies on animals. Recent controversies have arisen following the publication of a commentary suggesting a possible link between high fructose corn syrup (HFCS) consumption and obesity. Sinc...

متن کامل

I-54: New Models for Human and Mouse Genetic

The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...

متن کامل

Is Really Weather or Tropical Conditions Affects an Outbreak of COVID-19: A Brief Report

Corona viruses are large group of viruses that can cause sickness ranging from normal flu to severe respiratory diseases. The new novel corona virus (nCOV-19) or COVID-19 is a new kind of pandemic virus that did not identified before in humans. Global nations have heightened their surveillance in the quick diagnosis of potential cases across the COVID-19. After it had originated in China more c...

متن کامل

Bioarchaeology: Scientific Studies of Archaeological Human Skeletal Remains

Bioarchaeology is an interdisciplinary academic specialty, which through the scientific analysis and interpretation of archaeological human skeletal remains, bridges the link between the biological sciences, medicine, anthropology and social sciences. The cornerstone of bioarchaeology is the interaction between culture and human biology. Since the study of people and ancient societies is one of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Cancer research

دوره 53 10 Suppl  شماره 

صفحات  -

تاریخ انتشار 1993